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CROWE, JAMES

One or more keywords matched the following items that are connected to CROWE, JAMES

Item Type	Name
Academic Article	Generation of recombinant human monoclonal antibodies to rotavirus from single antigen-specific B cells selected with fluorescent virus-like particles.
Academic Article	Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes.
Academic Article	Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires.
Academic Article	VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7.
Academic Article	Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.
Academic Article	Transcriptional control of activation-induced cytidine deaminase and error-prone DNA polymerases is functionally mature in the B cells of infants at birth.
Academic Article	Functional maturation of the human antibody response to rotavirus.
Academic Article	Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones.
Academic Article	An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies.
Academic Article	An alphavirus replicon-based human metapneumovirus vaccine is immunogenic and protective in mice and cotton rats.
Academic Article	An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody.
Academic Article	A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin.
Academic Article	Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency.
Academic Article	Human germline antibody gene segments encode polyspecific antibodies.
Academic Article	Rotavirus-specific CD5+ B cells in young children exhibit a distinct antibody repertoire compared with CD5- B cells.
Academic Article	Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human na?ve and memory B cells.
Academic Article	A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo.
Academic Article	The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations.
Academic Article	Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus.
Academic Article	Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence.
Academic Article	Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes.
Academic Article	Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire.
Academic Article	Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore.
Concept	Immunoglobulin A
Concept	Immunoglobulin Joining Region
Concept	Receptors, IgG
Concept	Immunoglobulin J-Chains
Concept	Immunoglobulin Fragments
Concept	Immunoglobulin Heavy Chains
Concept	Immunoglobulin Isotypes
Concept	Immunoglobulin Variable Region
Concept	Somatic Hypermutation, Immunoglobulin
Concept	Immunoglobulin D
Concept	Genes, Immunoglobulin
Concept	Immunoglobulin Light Chains
Concept	Immunoglobulin Class Switching
Concept	Immunoglobulin Fc Fragments
Concept	Immunoglobulin Fab Fragments
Concept	Immunoglobulin G
Academic Article	A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface.
Academic Article	Tissue-specific expressed antibody variable gene repertoires.
Academic Article	Intracellular neutralization of a virus using a cell-penetrating molecular transporter.
Academic Article	A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Academic Article	Mechanism of human antibody-mediated neutralization of Marburg virus.
Academic Article	Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Academic Article	Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.
Academic Article	Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein.
Academic Article	Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.
Academic Article	Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.
Academic Article	Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates.
Academic Article	Long antibody HCDR3s from HIV-na?ve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.
Academic Article	Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints.
Academic Article	Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding.
Academic Article	Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody.
Academic Article	Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors.
Academic Article	Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors.
Academic Article	Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
Academic Article	A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus.
Academic Article	Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.
Academic Article	Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.
Academic Article	HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
Grant	RESPIRATORY VIRUS NEUTRALIZATION BY INTRACELLULAR AB
Academic Article	Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains.
Concept	Immunoglobulin Light-chain Amyloidosis
Academic Article	A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection.
Academic Article	Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge.
Academic Article	Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Academic Article	Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires.
Academic Article	Diverse patterns of antibody variable gene repertoire disruption in patients with amyloid light chain (AL) amyloidosis.
Academic Article	PyIR: a scalable wrapper for processing billions of immunoglobulin and T cell receptor sequences using IgBLAST.
Academic Article	Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring.
Academic Article	Discovery of Marburg virus neutralizing antibodies from virus-na?ve human antibody repertoires using large-scale structural predictions.
Academic Article	ClonoMatch: a tool for identifying homologous immunoglobulin and T-cell receptor sequences in large databases.
Academic Article	Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection.
Academic Article	Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein.
Academic Article	Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions.
Academic Article	Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.
Academic Article	A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope.
Academic Article	Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries.
Academic Article	An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies.
Academic Article	Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine.
Academic Article	Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode.

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Immunoglobulin G